Z424277
Aldrich
Combinatorial Chemistry: Synthesis, Analysis, Screening
| ISBN-10: | 352729869X |
| ISBN-13: | 978-352729869-3 |
Description
| General description | Combinatorial chemistry is a proven time- and resource-saving synthetic method of outstanding importance for industrial processes. Compound libraries help to save time and money, especially in the search for new drugs, and therefore play a pivotal role in solving the problem of the worldwide increasing demand for new and more active drugs. Not only substances, which are of interest for pharmaceutical chemistry, but also materials, catalysts, and biomolecules such as DNA or oligosaccharides are readily available with high structural diversities. The broad scope of combinatorial sciences is reflected by this book. The synthetic methods discussed range from solid-phase to solution-phase synthesis, from preparations of small molecules such as amines or alcohols to those of complex biomolecules. Feasible methods, efficient techniques, new trends in automation, and state-of-the-art fast instrumental analytical and screening methods are presented with many practical tips and tricks for everybody working in combinatorial chemistry. |
Properties
| publication info | G. Jung, ed., John Wiley & Sons, Ltd, 2001, 634 pp., hard cover |
Table Of Contents
| Table of Contents | Combinatorial Chemistry (D. Tiebes). Survey of Solid-Phase Organic Reactions (S. Booth, et al.). Solution-Phase Combinatorial Chemistry (V. Austel). Combinatorial Chemistry of Multicomponent Reactions (I. Ugi, et al.). Solid-Phase Anchors in Organic Chemistry (R. Warrass). The Use of Templates in Combinatorial Chemistry for the Solid Phase Synthesis of Multiple Core Structure Libraries Combinatorial Synthetic Oligomers (A. Bianco). Glycopeptide and Oligosaccharide Libraries (P. St. Hilaire & M. Meldal). RNA and DNA Aptamers (M. Famulok). Combinatorial Approaches to Molecular Receptors for Chemosensors (D. Leipert, et al.). Peptide Libraries in T-Cell-Mediated Immune Response (B. Fleckenstein, et al.). Combinatorial Biosynthesis of Microbial Metabolites (A. Bechthold & J. Fernández). Design and Diversity Analysis of Compound Libraries for Lead Discovery (H. Matter & M. Rarey). How to Scale-up While Scaling Down: EVOscreenTM, a Miniaturized Ultra High Throughput Screening System High Throughput Experimentation in Catalysis (F. Schüth, et al.). FT-Infrared Spectroscopy and IR-Microscopy for On Bead Analysis of Compound Libraries (H. Bandel, et al.). Mass Spectrometric Analysis of Combinatorially Generated Compounds and Libraries (R. Süßmuth, et al.). High Resolution Magic Angle Spinning (MAS) NMR Spectroscopy for On-Bead Analysis of Solid-Phase Synthesis Automated Combinatorial Chemistry (M. Winter, et al.). Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR-MS) for Analysis of Compound Libraries Index. |
